Q9MZJ2 and Q9MZK9
Less than 0.1 EU / ug
Expression system: Human Cells 293
Target sequence: Lys100-Leu233; Ser34-Ile179
N-8His and N-FLAG
Frum lyophilized from a filtered solution of 0.2 um of PBS, pH 7.4
NKG2A and CD94
NKG2-A contains a C-type lectin domain and belongs to the family of killer cell lectin-type receptors (KLRs). The KLR family is a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation.
CD94, also known as Killer cell lectin-like receptor (KLRD1) subfamily D member 1, is expressed on the surface of NK cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I human leukocyte antigen (HLA) E molecules by NK cells and some cytotoxic T cells. CD94 can form disulfide-linked heterodimers with NKG2A on the surface of NK cells. The CD94 / NKG2A complex interacts with HLA-E on target cells and inhibits the cytotoxic activity of NK cells to prevent cell lysis.